botheration

(noun) the psychological state of being irritated or annoyed. Synonyms: irritation, annoyance, vexation.

(noun) something or someone that causes trouble; a source of unhappiness. Synonyms: annoyance, bother, pain, infliction, pain in the neck, pain in the ass. Examples: "Washing dishes was a nuisance before we got a dish washer." "A bit of a bother." "He's not a friend, he's an infliction."