vexation

(noun) anger produced by some annoying irritation. Synonyms: annoyance, chafe.

(noun) the psychological state of being irritated or annoyed. Synonyms: irritation, annoyance, botheration.

(noun) something or someone that causes anxiety; a source of unhappiness. Synonyms: concern, worry, headache. Examples: "New york traffic is a constant concern." "It's a major worry."

(noun) the act of troubling or annoying someone. Synonyms: annoyance, annoying, irritation.