substance

(noun) the real physical matter of which a person or thing consists. Example: "Dna is the substance of our genes."

(noun) the choicest or most essential or most vital part of some idea or experience. Synonyms: kernel, core, center, centre, essence, gist, heart, heart and soul, inwardness, marrow, meat, nub, pith, sum, nitty-gritty. Examples: "The gist of the prosecutor's argument." "The heart and soul of the republican party." "The nub of the story."

(noun) the idea that is intended. Synonyms: meaning. Example: "What is the meaning of this proverb?."

(noun) material of a particular kind or constitution. Example: "The immune response recognizes invading substances."

(noun) considerable capital (wealth or income). Synonyms: means. Example: "He is a man of means."

(noun) what a communication that is about something is about. Synonyms: message, content, subject matter.

(noun) a particular kind or species of matter with uniform properties. Example: "Shigella is one of the most toxic substances known to man."