ssri sspe • sss · · · Info · Definitions · Synonyms · Characters · · ssri · · Text Latin · · Script 4 · · Length 1 · · Syllables Definitions · · · (noun) an antidepressant drug that acts by blocking the reuptake of serotonin so that more serotonin is available to act on receptors in the brain. Synonyms: selective-serotonin reuptake inhibitor, SSRI. · · Noun Definition 1 Synonyms · · · selective-serotonin reuptake inhibitor · · Synonym 1 Characters · · i latin small letter i U+0069 r latin small letter r U+0072 s latin small letter s U+0073