isolation

(noun) a state of separation between persons or groups.

(noun) a feeling of being disliked and alone.

(noun) the act of isolating something; setting something apart from others. Synonyms: closing off.

(noun) (psychiatry) a defense mechanism in which memory of an unacceptable act or impulse is separated from the emotion originally associated with it.

(noun) a country's withdrawal from international politics. Example: "He opposed a policy of american isolation."