hardship

(noun) a state of misfortune or affliction. Synonyms: adversity, hard knocks. Examples: "Debt-ridden farmers struggling with adversity." "A life of hardship."

(noun) something hard to endure. Synonyms: asperity, grimness, rigor, rigour, severity, severeness, rigorousness, rigourousness. Example: "The asperity of northern winters."

(noun) something that causes or entails suffering. Examples: "I cannot think it a hardship that more indulgence is allowed to men than to women"- james boswell." "The many hardships of frontier life."