despair

(noun) a state in which all hope is lost or absent. Synonyms: desperation. Examples: "In the depths of despair." "They were rescued from despair at the last minute." "Courage born of desperation."

(noun) the feeling that everything is wrong and nothing will turn out well. Examples: "They moaned in despair and dismay." "One harsh word would send her into the depths of despair."

(verb) abandon hope; give up hope; lose heart. Example: "Don't despair--help is on the way!."