crippling

(verb) deprive of strength or efficiency; make useless or worthless. Synonyms: cripple, stultify. Examples: "This measure crippled our efforts." "Their behavior stultified the boss's hard work."

(verb) deprive of the use of a limb, especially a leg. Synonyms: cripple, lame. Example: "The accident has crippled her for life."

(adj) that cripples or disables or incapacitates. Synonyms: disabling, incapacitating. Example: "A crippling injury."