afflicted

(verb) cause great unhappiness for; distress. Synonyms: afflict. Example: "She was afflicted by the death of her parents."

(verb) cause physical pain or suffering in. Synonyms: afflict, smite. Example: "Afflict with the plague."

(adj) grievously affected especially by disease. Synonyms: stricken.

(adj) mentally or physically unfit. Synonyms: impaired.