unhinged

(verb) disturb in mind or make uneasy or cause to be worried or alarmed. Synonyms: perturb, unhinge, disquiet, trouble, cark, distract, disorder. Example: "She was rather perturbed by the news that her father was seriously ill."

(verb) remove the hinges from. Synonyms: unhinge. Example: "Unhinge the door."

(adj) affected with madness or insanity. Synonyms: brainsick, crazy, demented, disturbed, mad, sick, unbalanced. Example: "A man who had gone mad."